The objectives of this course are to create a comprehensive understanding of the development of the embryology and malformation of the human system. The student will master the clinically relevant events of human development divided into trimesters of pregnancy. Key to this understanding are clinical applications associated with the development of connections of communication between neurons and associated brain experiences. The relationship between areas of the peripheral and central nervous system are presented specific to the development of the cerebral cortex. Plasticity of the nervous system as a consequence of activation is central to the understanding of maximizing human function. The functional maturity of the brain will be understood as a consequence of the development of communication through synaptic connections in the nervous system. Students will gain a contemporary knowledge of the adaptability of communication through activation and modulation of synapses. An understanding of the development and classification of receptors in the nervous system will promote an understanding of the applications and the contraindications to various pharmaceutical compounds. Students will understand the concepts of long-term potentiation, learning and executive functionality. The functional relationships of the cerebrospinal fluid and the development of the ventricular system of the brain will be presented with clinical applications.